RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
CDH1
RNA ID
RNA Type
mRNA
Alteration Pattern
promoter hypermethylation
Species
homo sapiens
Detection Methods
Immunofluorescence; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation
Year
2012
Function
"In bronchial epithelial cells, NiCl(2) induced EMT phenotype marker alterations such as up-regulation of fibronectin and down-regulation of E-cadherin. In addition, the potent antioxidant N-acetylcysteine blocked EMT and expression of HIF-1a induced by NiCl(2), whereas the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine restored the down-regulation of E-cadherin induced by NiCl(2). Promoter hypermethylation of E-cadherin was also induced by NiCl(2). Specifically, NiCl(2) induces down-regulation of E-cadherin by reactive oxygen species generation and promoter hypermethylation."